News & Events

Exciting news for CM²OST & Events at CWRU, ARMI, or in which we participate off-site

News

Staff News & Promotions

Professor Baskaran has been appointed Chair of the Department of Chemical and Biomolecular Engineering
Dr. Somoza has been promoted to Research Associate Professor

News

The Center for Modular Manufacturing of Structural Tissues is open and funded!

Case Western Reserve awarded $6.1 million from National Institute of Biomedical Imaging and Bioengineering to advance body tissue engineering

Publications

Harihara Baskaran

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.
Fattahi, P.; Rahimian, A.; Kihak, G.; Gonzalez-Suarez, A.; Slama, M.; Wolf, J.; Baskaran, H.; Stybayeva, Peterson, Q.; Duffy, C.; and Revzin, A.: Core-shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor Scientific Reports, 2021, 11(1):7177 PMID:33785778, PMCID: PMC8010084, DOI:10.1038/s41598-021-85786-2
Gong, X.; Yang, P.; Rohm, K.; Zhong, Y.; Zhao, B.; Manas-Zloczower, I.; Baskaran, H.; and Feke. D.L.: Porous hollow fibers with controllable structures templated from high internal phase emulsions. Journal of Applied Polymer Science, 2021, (Accepted)
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 27(19-20):1321-1332 doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734
Chariou, P.L.; Dogan, A.B.; Welsh, A.G.; Saidel, G.M.; Baskaran, H.; and Steinmetz, N.F.: Soil mobility of synthetic and virus-based model nanopesticides. Nat Nanotechnol. 2019 14(7):712-718. doi: 10.1038/s41565-019-0453-7. PMID: 31110265, PMCID: PMC6988359
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, PMCID: PMC6204100
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, PMCID: PMC6080111
Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 15(60):210-219 PMID: 28709984 PMCID: PMC5581212
Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-3003.
Thomas, D.G.; Yenepalli, A.; Denais, C.M.; Rape, A.; Beach, J.R.; Wang, Y.L.; Schiemann, W.P.; Baskaran, H.; Lammerding, J.; and Egelhoff, T.T.: Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. Journal of Cell Biology. 2015, 210(4):583-594. doi: 10.1083/jcb.201502039.
Rivera, A.L. and Baskaran, H.: The effect of biomolecular gradients on mesenchymal stem cell chondrogenesis under shear stress. Micromachines 2015, 6(3):330-346. doi:10.3390/mi6030330.
Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014 (Submitted)

Thomas J. Bollenbach

Climov, M.; Matar, A.J.; Farkash, E.A.; Medeiros, E.; Qiao, J.; Harrington, E.; Gusha, A.; Al-Musa, A.; Sachs, D.H.; Randolph, M.; Bollenbach, T.J.; and Huang, C.A.: Survival of allogeneic self-assembled cultured skin. Transplantation, 2016, 100(10):2071-2078. PMCID: PMC5030145; PMID: 27479166
Climov, M.; Medeiros, E.; Farkash, E.A.; Qiao, J.; Rousseau, C.F.; Dong, S.; Zawadzka, A.; Racki, W.J.; Al-Musa, A.; Sachs, D.H.; Randolph, M.A.; Huang, C.A.; and Bollenbach, T.J.: Bioengineered self-assembled skin as an alternative to skin grafts. Plast Reconstr Surg Glob Open, 2016, 4(6):e731. PMCID: PMC4956843, PMID: 27482479

Arnold I. Caplan

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.

Breitman M, Bonfield TL, Caplan AI, Lazarus HM, Haghiac M, LaSalvia S, Reese-Koc J, Singer NG.: Optimization of Human Mesenchymal Stem Cells for Rheumatoid Arthritis: Implications for Improved Therapeutic Outcomes. ACR Open Rheumatol. 2022 4(2):152-160. doi: 10.1002/acr2.11356.PMID: 34792869
Sorrel, J.M.; Somoza, R.A.; Baber, M.A.; Kenyon. J.; and Caplan. A.I.: Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells During Wound Healing. Cells. (submitted)
Vail, D.; Somoza, R.A.; and Caplan, A.I.: MicroRNA Regulation of Human Bone Marrow Derived Mesenchymal Stem Cells in vitro Chondrogenesis: Targeting the Pathway Towards Articular Cartilage Differentiation. Tissue Engineering part A (2021 Oct 25. doi: 10.1089/ten.TEA.2021.0112. Online ahead of print.
Nossin, Y.; Farrell, E.; Koevoet, W.D.; Somoza, R.A.; Caplan, A;I. and Van Osch, G.V.M.: The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo. Cartilage 2021 13(2_suppl):559S-570S. doi: 10.1177/19476035211047628.
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: CD146/MCAM Is an Adipogenic Marker for Mesenchymal Stem Cells, Adipose- Derived Stem Cells, and Dermal Fibroblasts.Â Frontiers in Bioengineering and Biotechnology. (submitted)
Bonfield, T.L.; Sutton, M.T.; Fletcher, D.R.; Folz, M.A.; Ragavapura, V.; Somoza, R.A.; and Caplan AI. Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium. Stem Cells Transl Med. 2021; 1– 15. PMID: 33943038 https://doi.org/10.1002/sctm.20-0521
Caplan, A.I.: Placebo Controls: Now??? Arch Immunol Ther Exp (Warsz) 2021 69(1):9. PMID: 33782781, PMCID: PMC8006883 DOI: 10.1007/s00005-021-00612-x
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 Jan 26. doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734.
Kerr, B.A.; Shi, L.; Jinnah, A.H.; Harris, K.S.; Willey, J.S.; Lennon, D.P.; Caplan, A.I.; and Byzova, T.V.: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. Exp Cell Res, 2021 399(2):112456 PMID: 33417921 PMCID: PMC7874523 (available on 2022-02-15) DOI: 10.1016/j.yexcr.2020.112456
Lanzoni, G.; Linetsky, E.; Correa, D.; Messinger Cayetano, S.; Alvarez, R.A.; Kouroupis, D.; Alvarez Gil, A.; Poggioli, R.; Ruiz, P.; Marttos, A.C.; Hirani, K.; Bell, C.A.; Kusack, H.; Rafkin, L.; Baidal, D.; Pastewski, A.; Gawri, K.; Leñero, C.; Mantero, A.M.A.; Metalonis, S.W.; Wang, X.; Roque, L.; Masters, B.; Kenyon, N.S.; Ginzburg, E.; Xu, X.; Tan, J.; Caplan, A.I.; Glassberg, M.K.; Alejandro, R.; and Ricordi, C.: Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. Stem Cells Transl Med. 2021, 10(5):660-673. doi: 10.1002/sctm.20-0472. PMID: 33400390.
Bukulmez, H.; Horkayne-Szakaly, I.; Bilgin, A.; Baker, T.P.; Caplan, A.I.; and Jones, O.Y.: Intrarenal injection of mesenchymal stem cell for treatment of lupus nephritis in mice – a pilot study. Lupus. 2021 Jan;30(1):52-60. doi: 10.1177/0961203320968897. PMID: 33135563
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Pittenger, M.F.; Discher, D.E.; Péault, B.M.; Phinney, D.G.; Hare, J.M.; and Caplan, A.I.: Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 4:22. doi: 10.1038/s41536-019-0083-6. eCollection 2019. Review. PMID: 31815001
Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002/term.2961.
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Li, M.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue engineering. Part A, 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.
Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and rat bone marrow-derived mesenchymal stem cells differ in their response to fibroblast growth factor and platelet-derived growth factor. Tissue Eng Part A. 2018 Aug 22. doi: 10.1089/ten.TEA.2018.0126. [Epub ahead of print]
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513. [Epub ahead of print]
Vail, D.; Somoza, R.; Caplan, A.; and Khalil, A.: Transcriptome dynamics of long non-coding RNAs and transcription factors demarcate human neonatal, adult, and MSC-derived engineered cartilage. Journal of Tissue Engineering and Regenerative Medicine (Submitted)
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 2018, PMID: 29948374, DOI: 10.1007/s10439-018-2067-x [Epub ahead of print]
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089/ten.TEA.2017.0438 [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Chondrogenesis of mesenchymal stem cell related to both -5p and -3p miRNAs. Tissue Eng Part A. 2018 May 24. doi: 10.1089/ten.TEA.2017.0440. [Epub ahead of print] PMID: 29676203
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002/jor.23820.
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559.
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 Aug 21. doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. (Submitted to Journal of Orthopaedic Research).
Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913.
Caplan, A.I.,; Mason, C.; and Reeve, B.: The 3Rs of Cell Therapy. Stem Cells Transl Med. 2016 Aug 8. pii: sctm.2016-0180. [Epub ahead of print]
Tremolada, C.; Ricordi, C.; Caplan, A.I,; and Ventura, C.: Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
Methods Mol Biol. 2016;1416:109-22. doi: 10.1007/978-1-4939-3584-0_6.
Shalev-Malul, G.; Soler, D.C.; Ting, A.E.; Lehman, N.A.; Barnboym, E.; McCormick, T.S.; Anthony, D.D.; Lazarus, H.M.; Caplan, A.I.; Breitman, M.; and Singer, N.G.: Development of a functional biomarker for use in cell-based therapy studies in seropositive rheumatoid arthritis. Stem Cells Transl Med. 2016 5(5):628-31.
Sutton, M.T.; Fletcher, D.; Ghosh, S.K.; Weinberg, A.; van Heeckeren, R.; Kaur, S.; Sadeghi, Z.; Hijaz, A.; Reese, J.; Lazarus, H.M.; Lennon, D.P.; Caplan, A.I.; and Bonfield, T.L.: Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection, and treatment. Stem Cells Int. 2016;2016:5303048. doi: 10.1155/2016/5303048. Epub 2016 Jan 26.
Caplan A.I.: MSCs: The sentinel and safe-guards of injury. J Cell Physiol. 2016 231(7):1413-1416.
Barker, N.M.; Carrino, D.A.; Caplan, A.I.; Hurd, W.W.; Liu, J.H.; Tan, H.; and Mesiano S.: Proteoglycans in leiomyoma and normal myometrium: abundance, steroid hormone control, and implications for pathophysiology. Reprod Sci. 2016 23(3):302-9.
Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. International Journal of Cancer, 2016 15;138(2):417-27.

Chung-Chiun Liu

Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; and Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angewandte Chemie International Ed In English, 2020, 59(46):20545-20551. PMID: 32835412
Tsai, J.P.; Jan, Y.T.; Yun, C.H.; Sung, K.T.; Liu, C.C.; Kuo, J.Y.; Hung, C.L.; Wu, T.H.; Lin, J.L.; Hou, C.J.; Yeh, H.I.; Bezerra, H.G.; and So, A.: Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship. PLoS One, 2020, 15(1):e0227680. PMCID: PMC6952096; PMID: 31917812
Xu, W.; Jin, T.; Dai, Y.; and Liu, C.C.: Surpassing the detection limit and accuracy of the electrochemical DNA sensor through the application of CRISPR Cas systems. Biosensors and Bioelectronics, 2020, 155:112100. PMID: 32090878
Ying, Z.; Feng, L.; Ji, D.; Zhang, Y.; Chen, W.; Dai, Y.; Janyasupab, M.; Li, X.; Wen, W.; and Liu, C.C.: Phase-Regulated Sensing Mechanism of MoS(2) Based Nanohybrids toward Point-of-Care Prostate Cancer Diagnosis. Small, 2020, 16(18):e2000307. PMID: 32250065
Dai, Y.; Chiu, L.Y.; Sui, Y.; Dai, Q.; Penumutchu, S.; Jain, N.; Dai, L.; Zorman, C.A.; Tolbert, B.S.; Sankaran, R.M.; and Liu, C.C.: Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions. Talanta, 2019, 195:46-54. PMID: 30625570
Dai, Y.; Furst, A.; and Liu, C.C.: Strand Displacement Strategies for Biosensor Applications. Trends in Biotechnology, 2019, 37(12):1367-1382. PMID: 31679827
Dai, Y. and Liu, C.C.: Recent Advances on Electrochemical Biosensing Strategies toward Universal Point-of-Care Systems. Angewandte Chemie International Ed In English, 2019, 58(36):12355-12368. PMID: 30990933
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angewandte Chemie International Ed In English, 2019, 58(48):17399-17405. PMCID: PMC6938695; PMID: 31568601
Xu, W.; Wang, D.; Li, D.; and Liu, C.C.: Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection. Int J Mol Sci, 2019, 21(1). PMCID: PMC6981776; PMID: 31878197
Xu, X.; Ji, D.; Zhang, Y.; Gao, X.; Xu, P.; Li, X.; Liu, C.C.; and Wen, W.: Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Appl Mater Interfaces, 2019, 11(23):20734-20742. PMID: 31094505
Dai, Y.; Abbasi, K.; DePietro, M.; Butler, S.; and Liu, C.C.: Advanced fabrication of biosensor on detection of Glypican-1 using S-Acetylmercaptosuccinic anhydride (SAMSA) modification of antibody. Sci Rep, 2018, 8(1):13541. PMCID: PMC6131508; PMID: 30202003
Dai, Y.; Molazemhosseini, A.; Abbasi, K.; and Liu, C.C.: A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution. Biosensors (Basel), 2018, 8(1). PMCID: PMC5872052; PMID: 29316652
Dai, Y.; Wang, C.; Chiu, L.Y.; Abbasi, K.; Tolbert, B.S.; Sauvé, G.; Yen, Y.; and Liu, C.C.: Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43. Biosensors and Bioelectronics, 2018, 117:60-67. PMCID: PMC6082407; PMID: 29885581
Sung, K.T.; Kuo, R.; Sun, J.Y.; Hung, T.C.; Chang, S.C.; Liu, C.C.; Yun, C.H.; Wu, T.H.; Hung, C.L.; Yeh, H.I.; Hou, C.J.; Cury, R.C.; Zidar, D.A.; Bezerra, H.G.; and Longenecker, C.T.: Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio. PLoS One, 2018, 13(11):e0207284. PMCID: PMC6245737; PMID: 30458019
Yao, J.; Wang, Y.; Dai, Y.; and Liu, C.C.: Bioconjugated, Single-Use Biosensor for the Detection of Biomarkers of Prostate Cancer. ACS Omega, 2018, 3(6):6411-6418. PMCID: PMC6044577; PMID: 30023946
Dai, Y. and Liu, C.C.: Detection of 17 β-Estradiol in Environmental Samples and for Health Care Using a Single-Use, Cost-Effective Biosensor Based on Differential Pulse Voltammetry (DPV). Biosensors (Basel), 2017, 7(2). PMCID: PMC5487957; PMID: 28353630
Dai, Y. and Liu, C.C.: A Simple, Cost-Effective Sensor for Detecting Lead Ions in Water Using Under-Potential Deposited Bismuth Sub-Layer with Differential Pulse Voltammetry (DPV). Sensors (Basel), 2017, 17(5). PMCID: PMC5461074; PMID: 28441356
Dai, Y.; Molazemhosseini, A.; and Liu, C.C.: In Vitro Quantified Determination of β-Amyloid 42 Peptides, a Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using a Simple, Cost-Effective Thin Gold Film Biosensor. Biosensors (Basel), 2017, 7(3). PMCID: PMC5618035; PMID: 28726727
Dai, Y.; Molazemhosseini, A.; and Liu, C.C.: A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using Differential Pulse Voltammetry (DPV). Biosensors (Basel), 2017, 7(1). PMCID: PMC5371783; PMID: 28218731
Molazemhosseini, A.; Magagnin, L.; Vena, P.; and Liu, C.C.: Single-Use Disposable Electrochemical Label-Free Immunosensor for Detection of Glycated Hemoglobin (HbA1c) Using Differential Pulse Voltammetry (DPV). Sensors (Basel), 2016, 16(7). PMCID: PMC4970074; PMID: 27376299
Yun, C.H.; Longenecker, C.T.; Chang, H.R.; Mok, G.S.; Sun, J.Y.; Liu, C.C.; Kuo, J.Y.; Hung, C.L.; Wu, T.H.; Yeh, H.I.; Yang, F.S.; Lee, J.J.; Hou, C.J.; Cury, R.C.; and Bezerra, H.G.: The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population. J Cardiovasc Comput Tomogr, 2016, 10(1):44-51. PMID: 26507645

Joseph M. Mansour

Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Mechanism of human fetal membrane biomechanical weakening, rupture and potential targets for therapeutic intervention. Obstet Gynecol Clin North Am. 2020 47(4):523-544. doi: 10.1016/j.ogc.2020.08.010. PMID: 33121643
Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604
Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.
Sharma, A.; Kumar, D.; Moore, R.M.; Deshmukh, A.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion. Placenta. 2020 89:1-7. doi: 10.1016/j.placenta.2019.10.003. PMID: 31665659
Kumar, D.; Moore, R.M.; Sharma, A.; Mercer, B.M.; Mansour, J.M.;and Moore, J.J.: In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening. Placenta. 2018 68:9-14. doi: 10.1016/j.placenta.2018.06.305. PMID: 30055672
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, 24(8):443-456 PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.
Whitney, G.A.; Kean, T.J.: Fernandes, R.J.; Waldman, S.; Tse, M.Y.; Pang, S.C.; Mansour, J.M.; and Dennis, J.E.: Thyroxine increases collagen type II expression and accumulation in scaffold-free tissue-engineered articular cartilage. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2016.0533. [Epub ahead of print]
Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; Redline, R.W.; and Moore, J.J.: The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. 2016, 42:59-73. doi: 10.1016/j.placenta.2016.03.015.
Zhou,H.; Gawlik, A.; Hernandez, C.; Goss, M.; Mansour,J.; and Exner, A.: Nondestructive characterization of biodegradable polymer erosion in vivo using ultrasound elastography imaging ACS Biomater. Sci. Eng. 2016 (Accepted)
Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering. 2016 44(3):733-749.
Zhou, H.; Goss, M.; Hernandez, C.; Mansour, J.M.; and Exner, A.: Validation of ultrasound elastography imaging for nondestructive characterization of stiffer biomaterials. Annals of Biomedical Engineering. 2016 44(5):1515-1523.

Seunghee Margevicius

Lipinski, J.; Margevicius, S.; Schluchter, M.D.; Wilson, D.L.; McComsey, G.A.; and Longenecker, C.T.: Statin effect on coronary calcium distribution, mass and volume scores and associations with immune activation among HIV+ persons on antiretroviral therapy. Antivir Ther. 2021 Apr 26. doi: 10.3851/IMP3389. PMID: 33901017. Online ahead of print.
Cummings, L.C.; Kou, T.D.; Chak, A.; Schluchter, M.D.; Margevicius, S.; and Cooper, G.S.: Receipt of serial endoscopy procedures prior to esophageal adenocarcinoma diagnosis is associated with better survival. Dig Dis Sci. 2021 Apr 21. doi: 10.1007/s10620-021-06927-1. PMID: 33881677. Online ahead of print.
Owusu, C.; Nock, N.L.; Feuntes, V.; Margevicius, S.; Hergenroeder, P.; Austin, K.; Bennet, E.; Cerne, S.; Moore, H.C.F.; Petkac, J.; Schluchter, M.; Schmitz, K.H.; Webb Hooper, M.; Coccia, S.; Nagy, C.; Wimbley, L.; and Berger, N.A.: IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and Non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Recruitment strategies and baseline characteristics. Cancer, 2021. PMID: 33539554
Peters, M.; Margevicius, S.; Kityo, C.; Mirembe, G.; Buggey, J.; Brinza, E.; Schluchter, M.; Yun, C.H.; Hung, C.L.; McComsey, G.A.; and Longenecker, C.T.: Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection. Journal of Acquired Immune Deficiency Syndromes, 2021, 86(1):104-109. PMID: 33044321
Hamilton, J.I.; Pahwa, S.; Adedigba, J.; Frankel, S.; O’Connor, G.; Thomas, R.; Walker, J.R.; Killinc, O.; Lo, W.C.; Batesole, J.; Margevicius, S.; Griswold, M.; Rajagopalan, S.; Gulani, V.; and Seiberlich, N.: Simultaneous Mapping of T(1) and T(2) Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T. Journal of Magnetic Resonance Imaging, 2020, 52(4):1044-1052. PMCID: PMC7772954; PMID: 32222092
Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater, 2020, 110. PMCID: PMC7493830; PMID: 32952604
Still, C.H.; Margevicius, S.; Harwell, C.; Huang, M.C.; Martin, L.; Dang, P.B.; and Wright Jnr, J.T.: A Community and Technology-Based Approach for Hypertension Self-Management (COACHMAN) to Improve Blood Pressure Control in African Americans: Results from a Pilot Study. Patient Prefer Adherence, 2020, 14:2301-2313. PMCID: PMC7695598; PMID: 33262580
Surdam, J.; Daly, B.; Fulton, S.; Margevicius, S.; Schluchter, M.; Flocke, S.; Manne, S.; and Meropol, N.J.: Recruitment Strategies for Nurse Enrollment in an Online Study. Nursing Research, 2020, 69(1):69-73. PMCID: PMC6911026; PMID: 31804433
Cummings Iii, K.C.; Kou, T.D.; Chak, A.; Schluchter, M.D.; Margevicius, S.; Cooper, G.S.; Meropol, N.J.; Perry, Y.; Linden, P.A.; and Cummings, L.C.: Surgical approach and the impact of epidural analgesia on survival after esophagectomy for cancer: A population-based retrospective cohort study. PLoS One, 2019, 14(1):e0211125. PMCID: PMC6342325; PMID: 30668599
Flocke, S.A.; Nock, N.L.; Fulton, S.; Margevicius, S.; Manne, S.; Meropol, N.J.; and Daly, B.J.: A National Study of Oncology Nurses Discussing Cancer Clinical Trials With Patients. Western Journal of Nursing Research, 2019, 41(12):1747-1760. PMCID: PMC6699918; PMID: 30782111
Panda, A.; Obmann, V.C.; Lo, W.C.; Margevicius, S.; Jiang, Y.; Schluchter, M.; Patel, I.J.; Nakamoto, D.; Badve, C.; Griswold, M.A.; Jaeger, I.; Ponsky, L.E.; and Gulani, V.: MR Fingerprinting and ADC Mapping for Characterization of Lesions in the Transition Zone of the Prostate Gland. Radiology, 2019, 292(3):685-694. PMCID: PMC6716564; PMID: 31335285
Panda, A.; OʼConnor, G.; Lo, W.C.; Jiang, Y.; Margevicius, S.; Schluchter, M.; Ponsky, L.E.; and Gulani, V.: Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping. Investigative Radiology, 2019, 54(8):485-493. PMCID: PMC6602844; PMID: 30985480
Babcook, M.A.; Akgul, M.; Margevicius, S.; MacLennan, G.T.; Fu, P.; Abouassaly, R.; and Gupta, S.: Ser-486/491 phosphorylation and inhibition of AMPKα activity is positively associated with Gleason score, metastasis, and castration-resistance in prostate cancer: A retrospective clinical study. Prostate, 2018, 78(10):714-723. PMCID: PMC6591712; PMID: 29577356
Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor. Tissue Eng Part A, 2018, 24(23-24):1831-1843. PMCID: PMC6302675; PMID: 29936884
Rodgers-Melnick, S.N.; Matthie, N.; Jenerette, C.; Griest Pell, T.J.; Lane, D.; Fu, P.; Margevicius, S.; and Little, J.A.: The Effects of a Single Electronic Music Improvisation Session on the Pain of Adults with Sickle Cell Disease: A Mixed Methods Pilot Study. J Music Ther, 2018, 55(2):156-185. PMID: 29796596
Badve, C.; Yu, A.; Dastmalchian, S.; Rogers, M.; Ma, D.; Jiang, Y.; Margevicius, S.; Pahwa, S.; Lu, Z.; Schluchter, M.; Sunshine, J.; Griswold, M.; Sloan, A.; and Gulani, V.: MR Fingerprinting of Adult Brain Tumors: Initial Experience. AJNR American Journal of Neuroradiology, 2017, 38(3):492-499. PMCID: PMC5352493; PMID: 28034994
Longenecker, C.T.; Margevicius, S.; Liu, Y.; Schluchter, M.D.; Yun, C.H.; Bezerra, H.G.; and McComsey, G.A.: Effect of Pericardial Fat Volume and Density on Markers of Insulin Resistance and Inflammation in Patients With Human Immunodeficiency Virus Infection. American Journal of Cardiology, 2017, 120(8):1427-1433. PMCID: PMC5614847; PMID: 28822563
Owusu, C.; Margevicius, S.; Schluchter, M.; Koroukian, S.M.; and Berger, N.A.: Short Physical Performance Battery, usual gait speed, grip strength and Vulnerable Elders Survey each predict functional decline among older women with breast cancer. J Geriatr Oncol, 2017, 8(5):356-362. PMCID: PMC5747299; PMID: 28743505
Rodgers-Melnick, S.N.; Pell, T.J.G.; Lane, D.; Jenerette, C.; Fu, P.; Margevicius, S.; and Little, J.A.: The effects of music therapy on transition outcomes in adolescents and young adults with sickle cell disease. Int J Adolesc Med Health, 2017, 31(3). PMID: 28779565
Yu, A.C.; Badve, C.; Ponsky, L.E.; Pahwa, S.; Dastmalchian, S.; Rogers, M.; Jiang, Y.; Margevicius, S.; Schluchter, M.; Tabayoyong, W.; Abouassaly, R.; McGivney, D.; Griswold, M.A.; and Gulani, V.: Development of a Combined MR Fingerprinting and Diffusion Examination for Prostate Cancer. Radiology, 2017, 283(3):729-738. PMCID: PMC5452885; PMID: 28187264
Meropol, N.J.; Wong, Y.N.; Albrecht, T.; Manne, S.; Miller, S.M.; Flamm, A.L.; Benson, A.B., 3rd; Buzaglo, J.; Collins, M.; Egleston, B.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Margevicius, S.; Miller, D.M.; Poole, D.; Roach, N.; Ross, E.; and Schluchter, M.D.: Randomized Trial of a Web-Based Intervention to Address Barriers to Clinical Trials. Journal of Clinical Oncology, 2016, 34(5):469-478. PMCID: PMC4872012 online at www.jco.org. Author contributions are found at the end of this article.; PMID: 26700123
Owusu, C.; Margevicius, S.; Schluchter, M.; Koroukian, S.M.; Schmitz, K.H.; and Berger, N.A.: Vulnerable elders survey and socioeconomic status predict functional decline and death among older women with newly diagnosed nonmetastatic breast cancer. Cancer, 2016, 122(16):2579-2586. PMCID: PMC5027843; PMID: 27348765
Wong, Y.N.; Schluchter, M.D.; Albrecht, T.L.; Benson, A.B., 3rd; Buzaglo, J.; Collins, M.; Flamm, A.L.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Manne, S.; Margevicius, S.; Miller, D.M.; Miller, S.M.; Poole, D.; Raivitch, S.; Roach, N.; Ross, E.; and Meropol, N.J.: Financial Concerns About Participation in Clinical Trials Among Patients With Cancer. Journal of Clinical Oncology, 2016, 34(5):479-487. PMCID: PMC4872013 online at www.jco.org. Author contributions are found at the end of this article.; PMID: 26700120

Richard McFarland

Lin-Gibson, S.; Lin, N.J.; Jackson, S.; Viswanathan, S.; Zylberberg, C.; Wolfrum, J.; Basu, S.; Roy, K.; Marshall. D.; McFarland, R.; Hoover, S.; Rietze, R.; Getz, A.; and Henke, D.: Standards efforts and landscape for rapid microbial testing methodologies in regenerative medicine. Cytotherapy. 2021 May;23(5):390-398. doi: 10.1016/j.jcyt.2020.07.006. PMID: 33775524
Tsokas, K.; McFarland, R.; Burke, C.; Lynch, J.L.; Bollenbach, T.; Callaway Ii, D.A.; and Siegel, J.: Reducing Risks and Delays in the Translation of Cell and Gene Therapy Innovations into Regulated Products. NAM Perspectives, 2019.
Haddock, R.; Lin-Gibson, S.; Lumelsky, N.; McFarland, R.; Roy, K.; Saha, K.; Zhang, J.; and Zylberberg, C. Manufacturing cell therapies: The paradigm shift in health care of this century. . NAM Perspectives; Washington, DC: National Academy of Medicine; 2017.
Witten, C.M.; McFarland, R.D.; and Simek, S.L.: Concise Review: The U.S. Food and Drug Administration and Regenerative Medicine. Stem Cells Transl Med, 2015, 4(12):1495-1499. PMCID: PMC4675507; PMID: 26494784

Mostafa Motavalli

Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604
Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, 24(8):443-456 PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, PMCID: PMC6204100

Rodrigo Somoza

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.
Sorrel, J.M.; Somoza, R.A.; Baber, M.A.; Kenyon. J.; and Caplan. A.I.: Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells During Wound Healing. Cells. (submitted)
Vail, D.; Somoza, R.A.; and Caplan, A.I.: MicroRNA Regulation of Human Bone Marrow Derived Mesenchymal Stem Cells in vitro Chondrogenesis: Targeting the Pathway Towards Articular Cartilage Differentiation. Tissue Engineering part A (submitted)
Nossin, Y.; Farrell, E.; Koevoet, W.D.; Somoza, R.A.; Caplan, A;I. and Van Osch, G.V.M.: Cartilage has a pro-angiogenic releasate. Cartilage (submitted)
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: CD146/MCAM Is an Adipogenic Marker for Mesenchymal Stem Cells, Adipose- Derived Stem Cells, and Dermal Fibroblasts.Â Frontiers in Bioengineering and Biotechnology. (submitted)
Bonfield, T.L.; Sutton, M.T.; Fletcher, D.R.; Folz, M.A.; Ragavapura, V.; Somoza, R.A.; and Caplan AI. Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium. Stem Cells Transl Med. 2021; 1– 15. PMID: 33943038 https://doi.org/10.1002/sctm.20-0521
Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191
Lennon, D.P.; Somoza, R.A.; Schluchter, M.A.; and Caplan, A.I.: The Habitat Assay, a Platform to Study In Vivo Properties of Human Mesenchymal Stem Cells. Tissue Eng Part A. 2020 26(23-24):1378-1387. PMID: 33107389 PMCID: PMC7759284 (available on 2021-12-01) DOI: 10.1089/ten.TEA.2020.0178
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002/term.2961. [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue Engineering 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002/jor.23820 Abstract
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Human mesenchymal stem cells (MSCs) do not make articular cartilage in vitro: Transcriptome-wide analyses of human neonatal cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering 2017 (Submitted)
Correa D.; Somoza, R.; Lin, P.; Schiemann, W.P.; and Caplan, A.I.: Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. International Journal of Cancer 2016 138(2):417-27

Jean F. Welter

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.
Jung, H.; Mclellan, P.; Welter, J.F.; and Akkus, O.: Chondrogenesis Mesenchymal Stem Cells via Local Release of TGFβ3 from Heparinized Collagen Biofabric. Tissue Eng Part A. 2021 Nov;27(21-22):1434-1445. DOI: 10.1089/ten.TEA.2020.0383. PMID: 33827271
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 27(19-20):1321-1332. doi: 10.1089/ten.TEA.2020.0144. PMID: 33499734
Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191
Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Larson, B.L.; Yu, S.N.; Park, H.; Estes, B.T.; Moutos, F.T.; Bloomquist, C.J.; Wu, P.B.; Welter, J.F.; Langer, R.; Guilak, F.; and Freed, L.E.: Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds. Journal of Tissue Engineering and Regenerative Medicine. 2019 doi: 10.1002/anie.2019107722019
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 24(8):443-456, 2018, PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, DOI: 10.1007/s10439-018-2067-x
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089/ten.TEA.2017.0438 (Epub ahead of print)</p
Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)
Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 doi: 10.1016/j.actbio.2017.07.016. [Epub ahead of print]
Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913.
Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering 2016 44(3):733-49.

Recent Publications

Harihara Baskaran

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.
Fattahi, P.; Rahimian, A.; Kihak, G.; Gonzalez-Suarez, A.; Slama, M.; Wolf, J.; Baskaran, H.; Stybayeva, Peterson, Q.; Duffy, C.; and Revzin, A.: Core-shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor Scientific Reports, 2021, 11(1):7177 PMID:33785778, PMCID: PMC8010084, DOI:10.1038/s41598-021-85786-2
Gong, X.; Yang, P.; Rohm, K.; Zhong, Y.; Zhao, B.; Manas-Zloczower, I.; Baskaran, H.; and Feke. D.L.: Porous hollow fibers with controllable structures templated from high internal phase emulsions. Journal of Applied Polymer Science, 2021, (Accepted)
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 27(19-20):1321-1332 doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734
Chariou, P.L.; Dogan, A.B.; Welsh, A.G.; Saidel, G.M.; Baskaran, H.; and Steinmetz, N.F.: Soil mobility of synthetic and virus-based model nanopesticides. Nat Nanotechnol. 2019 14(7):712-718. doi: 10.1038/s41565-019-0453-7. PMID: 31110265, PMCID: PMC6988359
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, PMCID: PMC6204100
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, PMCID: PMC6080111
Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 15(60):210-219 PMID: 28709984 PMCID: PMC5581212
Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-3003.
Thomas, D.G.; Yenepalli, A.; Denais, C.M.; Rape, A.; Beach, J.R.; Wang, Y.L.; Schiemann, W.P.; Baskaran, H.; Lammerding, J.; and Egelhoff, T.T.: Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. Journal of Cell Biology. 2015, 210(4):583-594. doi: 10.1083/jcb.201502039.
Rivera, A.L. and Baskaran, H.: The effect of biomolecular gradients on mesenchymal stem cell chondrogenesis under shear stress. Micromachines 2015, 6(3):330-346. doi:10.3390/mi6030330.
Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014 (Submitted)

Thomas J. Bollenbach

Climov, M.; Matar, A.J.; Farkash, E.A.; Medeiros, E.; Qiao, J.; Harrington, E.; Gusha, A.; Al-Musa, A.; Sachs, D.H.; Randolph, M.; Bollenbach, T.J.; and Huang, C.A.: Survival of allogeneic self-assembled cultured skin. Transplantation, 2016, 100(10):2071-2078. PMCID: PMC5030145; PMID: 27479166
Climov, M.; Medeiros, E.; Farkash, E.A.; Qiao, J.; Rousseau, C.F.; Dong, S.; Zawadzka, A.; Racki, W.J.; Al-Musa, A.; Sachs, D.H.; Randolph, M.A.; Huang, C.A.; and Bollenbach, T.J.: Bioengineered self-assembled skin as an alternative to skin grafts. Plast Reconstr Surg Glob Open, 2016, 4(6):e731. PMCID: PMC4956843, PMID: 27482479

Arnold I. Caplan

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.

Breitman M, Bonfield TL, Caplan AI, Lazarus HM, Haghiac M, LaSalvia S, Reese-Koc J, Singer NG.: Optimization of Human Mesenchymal Stem Cells for Rheumatoid Arthritis: Implications for Improved Therapeutic Outcomes. ACR Open Rheumatol. 2022 4(2):152-160. doi: 10.1002/acr2.11356.PMID: 34792869
Sorrel, J.M.; Somoza, R.A.; Baber, M.A.; Kenyon. J.; and Caplan. A.I.: Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells During Wound Healing. Cells. (submitted)
Vail, D.; Somoza, R.A.; and Caplan, A.I.: MicroRNA Regulation of Human Bone Marrow Derived Mesenchymal Stem Cells in vitro Chondrogenesis: Targeting the Pathway Towards Articular Cartilage Differentiation. Tissue Engineering part A (2021 Oct 25. doi: 10.1089/ten.TEA.2021.0112. Online ahead of print.
Nossin, Y.; Farrell, E.; Koevoet, W.D.; Somoza, R.A.; Caplan, A;I. and Van Osch, G.V.M.: The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo. Cartilage 2021 13(2_suppl):559S-570S. doi: 10.1177/19476035211047628.
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: CD146/MCAM Is an Adipogenic Marker for Mesenchymal Stem Cells, Adipose- Derived Stem Cells, and Dermal Fibroblasts.Â Frontiers in Bioengineering and Biotechnology. (submitted)
Bonfield, T.L.; Sutton, M.T.; Fletcher, D.R.; Folz, M.A.; Ragavapura, V.; Somoza, R.A.; and Caplan AI. Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium. Stem Cells Transl Med. 2021; 1– 15. PMID: 33943038 https://doi.org/10.1002/sctm.20-0521
Caplan, A.I.: Placebo Controls: Now??? Arch Immunol Ther Exp (Warsz) 2021 69(1):9. PMID: 33782781, PMCID: PMC8006883 DOI: 10.1007/s00005-021-00612-x
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 Jan 26. doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734.
Kerr, B.A.; Shi, L.; Jinnah, A.H.; Harris, K.S.; Willey, J.S.; Lennon, D.P.; Caplan, A.I.; and Byzova, T.V.: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. Exp Cell Res, 2021 399(2):112456 PMID: 33417921 PMCID: PMC7874523 (available on 2022-02-15) DOI: 10.1016/j.yexcr.2020.112456
Lanzoni, G.; Linetsky, E.; Correa, D.; Messinger Cayetano, S.; Alvarez, R.A.; Kouroupis, D.; Alvarez Gil, A.; Poggioli, R.; Ruiz, P.; Marttos, A.C.; Hirani, K.; Bell, C.A.; Kusack, H.; Rafkin, L.; Baidal, D.; Pastewski, A.; Gawri, K.; Leñero, C.; Mantero, A.M.A.; Metalonis, S.W.; Wang, X.; Roque, L.; Masters, B.; Kenyon, N.S.; Ginzburg, E.; Xu, X.; Tan, J.; Caplan, A.I.; Glassberg, M.K.; Alejandro, R.; and Ricordi, C.: Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. Stem Cells Transl Med. 2021, 10(5):660-673. doi: 10.1002/sctm.20-0472. PMID: 33400390.
Bukulmez, H.; Horkayne-Szakaly, I.; Bilgin, A.; Baker, T.P.; Caplan, A.I.; and Jones, O.Y.: Intrarenal injection of mesenchymal stem cell for treatment of lupus nephritis in mice – a pilot study. Lupus. 2021 Jan;30(1):52-60. doi: 10.1177/0961203320968897. PMID: 33135563
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Pittenger, M.F.; Discher, D.E.; Péault, B.M.; Phinney, D.G.; Hare, J.M.; and Caplan, A.I.: Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 4:22. doi: 10.1038/s41536-019-0083-6. eCollection 2019. Review. PMID: 31815001
Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002/term.2961.
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Li, M.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue engineering. Part A, 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.
Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and rat bone marrow-derived mesenchymal stem cells differ in their response to fibroblast growth factor and platelet-derived growth factor. Tissue Eng Part A. 2018 Aug 22. doi: 10.1089/ten.TEA.2018.0126. [Epub ahead of print]
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513. [Epub ahead of print]
Vail, D.; Somoza, R.; Caplan, A.; and Khalil, A.: Transcriptome dynamics of long non-coding RNAs and transcription factors demarcate human neonatal, adult, and MSC-derived engineered cartilage. Journal of Tissue Engineering and Regenerative Medicine (Submitted)
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 2018, PMID: 29948374, DOI: 10.1007/s10439-018-2067-x [Epub ahead of print]
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089/ten.TEA.2017.0438 [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Chondrogenesis of mesenchymal stem cell related to both -5p and -3p miRNAs. Tissue Eng Part A. 2018 May 24. doi: 10.1089/ten.TEA.2017.0440. [Epub ahead of print] PMID: 29676203
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002/jor.23820.
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559.
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 Aug 21. doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. (Submitted to Journal of Orthopaedic Research).
Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913.
Caplan, A.I.,; Mason, C.; and Reeve, B.: The 3Rs of Cell Therapy. Stem Cells Transl Med. 2016 Aug 8. pii: sctm.2016-0180. [Epub ahead of print]
Tremolada, C.; Ricordi, C.; Caplan, A.I,; and Ventura, C.: Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
Methods Mol Biol. 2016;1416:109-22. doi: 10.1007/978-1-4939-3584-0_6.
Shalev-Malul, G.; Soler, D.C.; Ting, A.E.; Lehman, N.A.; Barnboym, E.; McCormick, T.S.; Anthony, D.D.; Lazarus, H.M.; Caplan, A.I.; Breitman, M.; and Singer, N.G.: Development of a functional biomarker for use in cell-based therapy studies in seropositive rheumatoid arthritis. Stem Cells Transl Med. 2016 5(5):628-31.
Sutton, M.T.; Fletcher, D.; Ghosh, S.K.; Weinberg, A.; van Heeckeren, R.; Kaur, S.; Sadeghi, Z.; Hijaz, A.; Reese, J.; Lazarus, H.M.; Lennon, D.P.; Caplan, A.I.; and Bonfield, T.L.: Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection, and treatment. Stem Cells Int. 2016;2016:5303048. doi: 10.1155/2016/5303048. Epub 2016 Jan 26.
Caplan A.I.: MSCs: The sentinel and safe-guards of injury. J Cell Physiol. 2016 231(7):1413-1416.
Barker, N.M.; Carrino, D.A.; Caplan, A.I.; Hurd, W.W.; Liu, J.H.; Tan, H.; and Mesiano S.: Proteoglycans in leiomyoma and normal myometrium: abundance, steroid hormone control, and implications for pathophysiology. Reprod Sci. 2016 23(3):302-9.
Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. International Journal of Cancer, 2016 15;138(2):417-27.

Chung-Chiun Liu

Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; and Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angewandte Chemie International Ed In English, 2020, 59(46):20545-20551. PMID: 32835412
Tsai, J.P.; Jan, Y.T.; Yun, C.H.; Sung, K.T.; Liu, C.C.; Kuo, J.Y.; Hung, C.L.; Wu, T.H.; Lin, J.L.; Hou, C.J.; Yeh, H.I.; Bezerra, H.G.; and So, A.: Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship. PLoS One, 2020, 15(1):e0227680. PMCID: PMC6952096; PMID: 31917812
Xu, W.; Jin, T.; Dai, Y.; and Liu, C.C.: Surpassing the detection limit and accuracy of the electrochemical DNA sensor through the application of CRISPR Cas systems. Biosensors and Bioelectronics, 2020, 155:112100. PMID: 32090878
Ying, Z.; Feng, L.; Ji, D.; Zhang, Y.; Chen, W.; Dai, Y.; Janyasupab, M.; Li, X.; Wen, W.; and Liu, C.C.: Phase-Regulated Sensing Mechanism of MoS(2) Based Nanohybrids toward Point-of-Care Prostate Cancer Diagnosis. Small, 2020, 16(18):e2000307. PMID: 32250065
Dai, Y.; Chiu, L.Y.; Sui, Y.; Dai, Q.; Penumutchu, S.; Jain, N.; Dai, L.; Zorman, C.A.; Tolbert, B.S.; Sankaran, R.M.; and Liu, C.C.: Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions. Talanta, 2019, 195:46-54. PMID: 30625570
Dai, Y.; Furst, A.; and Liu, C.C.: Strand Displacement Strategies for Biosensor Applications. Trends in Biotechnology, 2019, 37(12):1367-1382. PMID: 31679827
Dai, Y. and Liu, C.C.: Recent Advances on Electrochemical Biosensing Strategies toward Universal Point-of-Care Systems. Angewandte Chemie International Ed In English, 2019, 58(36):12355-12368. PMID: 30990933
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angewandte Chemie International Ed In English, 2019, 58(48):17399-17405. PMCID: PMC6938695; PMID: 31568601
Xu, W.; Wang, D.; Li, D.; and Liu, C.C.: Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection. Int J Mol Sci, 2019, 21(1). PMCID: PMC6981776; PMID: 31878197
Xu, X.; Ji, D.; Zhang, Y.; Gao, X.; Xu, P.; Li, X.; Liu, C.C.; and Wen, W.: Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Appl Mater Interfaces, 2019, 11(23):20734-20742. PMID: 31094505
Dai, Y.; Abbasi, K.; DePietro, M.; Butler, S.; and Liu, C.C.: Advanced fabrication of biosensor on detection of Glypican-1 using S-Acetylmercaptosuccinic anhydride (SAMSA) modification of antibody. Sci Rep, 2018, 8(1):13541. PMCID: PMC6131508; PMID: 30202003
Dai, Y.; Molazemhosseini, A.; Abbasi, K.; and Liu, C.C.: A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution. Biosensors (Basel), 2018, 8(1). PMCID: PMC5872052; PMID: 29316652
Dai, Y.; Wang, C.; Chiu, L.Y.; Abbasi, K.; Tolbert, B.S.; Sauvé, G.; Yen, Y.; and Liu, C.C.: Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43. Biosensors and Bioelectronics, 2018, 117:60-67. PMCID: PMC6082407; PMID: 29885581
Sung, K.T.; Kuo, R.; Sun, J.Y.; Hung, T.C.; Chang, S.C.; Liu, C.C.; Yun, C.H.; Wu, T.H.; Hung, C.L.; Yeh, H.I.; Hou, C.J.; Cury, R.C.; Zidar, D.A.; Bezerra, H.G.; and Longenecker, C.T.: Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio. PLoS One, 2018, 13(11):e0207284. PMCID: PMC6245737; PMID: 30458019
Yao, J.; Wang, Y.; Dai, Y.; and Liu, C.C.: Bioconjugated, Single-Use Biosensor for the Detection of Biomarkers of Prostate Cancer. ACS Omega, 2018, 3(6):6411-6418. PMCID: PMC6044577; PMID: 30023946
Dai, Y. and Liu, C.C.: Detection of 17 β-Estradiol in Environmental Samples and for Health Care Using a Single-Use, Cost-Effective Biosensor Based on Differential Pulse Voltammetry (DPV). Biosensors (Basel), 2017, 7(2). PMCID: PMC5487957; PMID: 28353630
Dai, Y. and Liu, C.C.: A Simple, Cost-Effective Sensor for Detecting Lead Ions in Water Using Under-Potential Deposited Bismuth Sub-Layer with Differential Pulse Voltammetry (DPV). Sensors (Basel), 2017, 17(5). PMCID: PMC5461074; PMID: 28441356
Dai, Y.; Molazemhosseini, A.; and Liu, C.C.: In Vitro Quantified Determination of β-Amyloid 42 Peptides, a Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using a Simple, Cost-Effective Thin Gold Film Biosensor. Biosensors (Basel), 2017, 7(3). PMCID: PMC5618035; PMID: 28726727
Dai, Y.; Molazemhosseini, A.; and Liu, C.C.: A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using Differential Pulse Voltammetry (DPV). Biosensors (Basel), 2017, 7(1). PMCID: PMC5371783; PMID: 28218731
Molazemhosseini, A.; Magagnin, L.; Vena, P.; and Liu, C.C.: Single-Use Disposable Electrochemical Label-Free Immunosensor for Detection of Glycated Hemoglobin (HbA1c) Using Differential Pulse Voltammetry (DPV). Sensors (Basel), 2016, 16(7). PMCID: PMC4970074; PMID: 27376299
Yun, C.H.; Longenecker, C.T.; Chang, H.R.; Mok, G.S.; Sun, J.Y.; Liu, C.C.; Kuo, J.Y.; Hung, C.L.; Wu, T.H.; Yeh, H.I.; Yang, F.S.; Lee, J.J.; Hou, C.J.; Cury, R.C.; and Bezerra, H.G.: The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population. J Cardiovasc Comput Tomogr, 2016, 10(1):44-51. PMID: 26507645

Joseph M. Mansour

Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Mechanism of human fetal membrane biomechanical weakening, rupture and potential targets for therapeutic intervention. Obstet Gynecol Clin North Am. 2020 47(4):523-544. doi: 10.1016/j.ogc.2020.08.010. PMID: 33121643
Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604
Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.
Sharma, A.; Kumar, D.; Moore, R.M.; Deshmukh, A.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion. Placenta. 2020 89:1-7. doi: 10.1016/j.placenta.2019.10.003. PMID: 31665659
Kumar, D.; Moore, R.M.; Sharma, A.; Mercer, B.M.; Mansour, J.M.;and Moore, J.J.: In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening. Placenta. 2018 68:9-14. doi: 10.1016/j.placenta.2018.06.305. PMID: 30055672
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, 24(8):443-456 PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.
Whitney, G.A.; Kean, T.J.: Fernandes, R.J.; Waldman, S.; Tse, M.Y.; Pang, S.C.; Mansour, J.M.; and Dennis, J.E.: Thyroxine increases collagen type II expression and accumulation in scaffold-free tissue-engineered articular cartilage. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2016.0533. [Epub ahead of print]
Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; Redline, R.W.; and Moore, J.J.: The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. 2016, 42:59-73. doi: 10.1016/j.placenta.2016.03.015.
Zhou,H.; Gawlik, A.; Hernandez, C.; Goss, M.; Mansour,J.; and Exner, A.: Nondestructive characterization of biodegradable polymer erosion in vivo using ultrasound elastography imaging ACS Biomater. Sci. Eng. 2016 (Accepted)
Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering. 2016 44(3):733-749.
Zhou, H.; Goss, M.; Hernandez, C.; Mansour, J.M.; and Exner, A.: Validation of ultrasound elastography imaging for nondestructive characterization of stiffer biomaterials. Annals of Biomedical Engineering. 2016 44(5):1515-1523.

Seunghee Margevicius

Lipinski, J.; Margevicius, S.; Schluchter, M.D.; Wilson, D.L.; McComsey, G.A.; and Longenecker, C.T.: Statin effect on coronary calcium distribution, mass and volume scores and associations with immune activation among HIV+ persons on antiretroviral therapy. Antivir Ther. 2021 Apr 26. doi: 10.3851/IMP3389. PMID: 33901017. Online ahead of print.
Cummings, L.C.; Kou, T.D.; Chak, A.; Schluchter, M.D.; Margevicius, S.; and Cooper, G.S.: Receipt of serial endoscopy procedures prior to esophageal adenocarcinoma diagnosis is associated with better survival. Dig Dis Sci. 2021 Apr 21. doi: 10.1007/s10620-021-06927-1. PMID: 33881677. Online ahead of print.
Owusu, C.; Nock, N.L.; Feuntes, V.; Margevicius, S.; Hergenroeder, P.; Austin, K.; Bennet, E.; Cerne, S.; Moore, H.C.F.; Petkac, J.; Schluchter, M.; Schmitz, K.H.; Webb Hooper, M.; Coccia, S.; Nagy, C.; Wimbley, L.; and Berger, N.A.: IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and Non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Recruitment strategies and baseline characteristics. Cancer, 2021. PMID: 33539554
Peters, M.; Margevicius, S.; Kityo, C.; Mirembe, G.; Buggey, J.; Brinza, E.; Schluchter, M.; Yun, C.H.; Hung, C.L.; McComsey, G.A.; and Longenecker, C.T.: Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection. Journal of Acquired Immune Deficiency Syndromes, 2021, 86(1):104-109. PMID: 33044321
Hamilton, J.I.; Pahwa, S.; Adedigba, J.; Frankel, S.; O’Connor, G.; Thomas, R.; Walker, J.R.; Killinc, O.; Lo, W.C.; Batesole, J.; Margevicius, S.; Griswold, M.; Rajagopalan, S.; Gulani, V.; and Seiberlich, N.: Simultaneous Mapping of T(1) and T(2) Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T. Journal of Magnetic Resonance Imaging, 2020, 52(4):1044-1052. PMCID: PMC7772954; PMID: 32222092
Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater, 2020, 110. PMCID: PMC7493830; PMID: 32952604
Still, C.H.; Margevicius, S.; Harwell, C.; Huang, M.C.; Martin, L.; Dang, P.B.; and Wright Jnr, J.T.: A Community and Technology-Based Approach for Hypertension Self-Management (COACHMAN) to Improve Blood Pressure Control in African Americans: Results from a Pilot Study. Patient Prefer Adherence, 2020, 14:2301-2313. PMCID: PMC7695598; PMID: 33262580
Surdam, J.; Daly, B.; Fulton, S.; Margevicius, S.; Schluchter, M.; Flocke, S.; Manne, S.; and Meropol, N.J.: Recruitment Strategies for Nurse Enrollment in an Online Study. Nursing Research, 2020, 69(1):69-73. PMCID: PMC6911026; PMID: 31804433
Cummings Iii, K.C.; Kou, T.D.; Chak, A.; Schluchter, M.D.; Margevicius, S.; Cooper, G.S.; Meropol, N.J.; Perry, Y.; Linden, P.A.; and Cummings, L.C.: Surgical approach and the impact of epidural analgesia on survival after esophagectomy for cancer: A population-based retrospective cohort study. PLoS One, 2019, 14(1):e0211125. PMCID: PMC6342325; PMID: 30668599
Flocke, S.A.; Nock, N.L.; Fulton, S.; Margevicius, S.; Manne, S.; Meropol, N.J.; and Daly, B.J.: A National Study of Oncology Nurses Discussing Cancer Clinical Trials With Patients. Western Journal of Nursing Research, 2019, 41(12):1747-1760. PMCID: PMC6699918; PMID: 30782111
Panda, A.; Obmann, V.C.; Lo, W.C.; Margevicius, S.; Jiang, Y.; Schluchter, M.; Patel, I.J.; Nakamoto, D.; Badve, C.; Griswold, M.A.; Jaeger, I.; Ponsky, L.E.; and Gulani, V.: MR Fingerprinting and ADC Mapping for Characterization of Lesions in the Transition Zone of the Prostate Gland. Radiology, 2019, 292(3):685-694. PMCID: PMC6716564; PMID: 31335285
Panda, A.; OʼConnor, G.; Lo, W.C.; Jiang, Y.; Margevicius, S.; Schluchter, M.; Ponsky, L.E.; and Gulani, V.: Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping. Investigative Radiology, 2019, 54(8):485-493. PMCID: PMC6602844; PMID: 30985480
Babcook, M.A.; Akgul, M.; Margevicius, S.; MacLennan, G.T.; Fu, P.; Abouassaly, R.; and Gupta, S.: Ser-486/491 phosphorylation and inhibition of AMPKα activity is positively associated with Gleason score, metastasis, and castration-resistance in prostate cancer: A retrospective clinical study. Prostate, 2018, 78(10):714-723. PMCID: PMC6591712; PMID: 29577356
Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor. Tissue Eng Part A, 2018, 24(23-24):1831-1843. PMCID: PMC6302675; PMID: 29936884
Rodgers-Melnick, S.N.; Matthie, N.; Jenerette, C.; Griest Pell, T.J.; Lane, D.; Fu, P.; Margevicius, S.; and Little, J.A.: The Effects of a Single Electronic Music Improvisation Session on the Pain of Adults with Sickle Cell Disease: A Mixed Methods Pilot Study. J Music Ther, 2018, 55(2):156-185. PMID: 29796596
Badve, C.; Yu, A.; Dastmalchian, S.; Rogers, M.; Ma, D.; Jiang, Y.; Margevicius, S.; Pahwa, S.; Lu, Z.; Schluchter, M.; Sunshine, J.; Griswold, M.; Sloan, A.; and Gulani, V.: MR Fingerprinting of Adult Brain Tumors: Initial Experience. AJNR American Journal of Neuroradiology, 2017, 38(3):492-499. PMCID: PMC5352493; PMID: 28034994
Longenecker, C.T.; Margevicius, S.; Liu, Y.; Schluchter, M.D.; Yun, C.H.; Bezerra, H.G.; and McComsey, G.A.: Effect of Pericardial Fat Volume and Density on Markers of Insulin Resistance and Inflammation in Patients With Human Immunodeficiency Virus Infection. American Journal of Cardiology, 2017, 120(8):1427-1433. PMCID: PMC5614847; PMID: 28822563
Owusu, C.; Margevicius, S.; Schluchter, M.; Koroukian, S.M.; and Berger, N.A.: Short Physical Performance Battery, usual gait speed, grip strength and Vulnerable Elders Survey each predict functional decline among older women with breast cancer. J Geriatr Oncol, 2017, 8(5):356-362. PMCID: PMC5747299; PMID: 28743505
Rodgers-Melnick, S.N.; Pell, T.J.G.; Lane, D.; Jenerette, C.; Fu, P.; Margevicius, S.; and Little, J.A.: The effects of music therapy on transition outcomes in adolescents and young adults with sickle cell disease. Int J Adolesc Med Health, 2017, 31(3). PMID: 28779565
Yu, A.C.; Badve, C.; Ponsky, L.E.; Pahwa, S.; Dastmalchian, S.; Rogers, M.; Jiang, Y.; Margevicius, S.; Schluchter, M.; Tabayoyong, W.; Abouassaly, R.; McGivney, D.; Griswold, M.A.; and Gulani, V.: Development of a Combined MR Fingerprinting and Diffusion Examination for Prostate Cancer. Radiology, 2017, 283(3):729-738. PMCID: PMC5452885; PMID: 28187264
Meropol, N.J.; Wong, Y.N.; Albrecht, T.; Manne, S.; Miller, S.M.; Flamm, A.L.; Benson, A.B., 3rd; Buzaglo, J.; Collins, M.; Egleston, B.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Margevicius, S.; Miller, D.M.; Poole, D.; Roach, N.; Ross, E.; and Schluchter, M.D.: Randomized Trial of a Web-Based Intervention to Address Barriers to Clinical Trials. Journal of Clinical Oncology, 2016, 34(5):469-478. PMCID: PMC4872012 online at www.jco.org. Author contributions are found at the end of this article.; PMID: 26700123
Owusu, C.; Margevicius, S.; Schluchter, M.; Koroukian, S.M.; Schmitz, K.H.; and Berger, N.A.: Vulnerable elders survey and socioeconomic status predict functional decline and death among older women with newly diagnosed nonmetastatic breast cancer. Cancer, 2016, 122(16):2579-2586. PMCID: PMC5027843; PMID: 27348765
Wong, Y.N.; Schluchter, M.D.; Albrecht, T.L.; Benson, A.B., 3rd; Buzaglo, J.; Collins, M.; Flamm, A.L.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Manne, S.; Margevicius, S.; Miller, D.M.; Miller, S.M.; Poole, D.; Raivitch, S.; Roach, N.; Ross, E.; and Meropol, N.J.: Financial Concerns About Participation in Clinical Trials Among Patients With Cancer. Journal of Clinical Oncology, 2016, 34(5):479-487. PMCID: PMC4872013 online at www.jco.org. Author contributions are found at the end of this article.; PMID: 26700120

Richard McFarland

Lin-Gibson, S.; Lin, N.J.; Jackson, S.; Viswanathan, S.; Zylberberg, C.; Wolfrum, J.; Basu, S.; Roy, K.; Marshall. D.; McFarland, R.; Hoover, S.; Rietze, R.; Getz, A.; and Henke, D.: Standards efforts and landscape for rapid microbial testing methodologies in regenerative medicine. Cytotherapy. 2021 May;23(5):390-398. doi: 10.1016/j.jcyt.2020.07.006. PMID: 33775524
Tsokas, K.; McFarland, R.; Burke, C.; Lynch, J.L.; Bollenbach, T.; Callaway Ii, D.A.; and Siegel, J.: Reducing Risks and Delays in the Translation of Cell and Gene Therapy Innovations into Regulated Products. NAM Perspectives, 2019.
Haddock, R.; Lin-Gibson, S.; Lumelsky, N.; McFarland, R.; Roy, K.; Saha, K.; Zhang, J.; and Zylberberg, C. Manufacturing cell therapies: The paradigm shift in health care of this century. . NAM Perspectives; Washington, DC: National Academy of Medicine; 2017.
Witten, C.M.; McFarland, R.D.; and Simek, S.L.: Concise Review: The U.S. Food and Drug Administration and Regenerative Medicine. Stem Cells Transl Med, 2015, 4(12):1495-1499. PMCID: PMC4675507; PMID: 26494784

Mostafa Motavalli

Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604
Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, 24(8):443-456 PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, PMCID: PMC6204100

Rodrigo Somoza

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.
Sorrel, J.M.; Somoza, R.A.; Baber, M.A.; Kenyon. J.; and Caplan. A.I.: Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells During Wound Healing. Cells. (submitted)
Vail, D.; Somoza, R.A.; and Caplan, A.I.: MicroRNA Regulation of Human Bone Marrow Derived Mesenchymal Stem Cells in vitro Chondrogenesis: Targeting the Pathway Towards Articular Cartilage Differentiation. Tissue Engineering part A (submitted)
Nossin, Y.; Farrell, E.; Koevoet, W.D.; Somoza, R.A.; Caplan, A;I. and Van Osch, G.V.M.: Cartilage has a pro-angiogenic releasate. Cartilage (submitted)
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: CD146/MCAM Is an Adipogenic Marker for Mesenchymal Stem Cells, Adipose- Derived Stem Cells, and Dermal Fibroblasts.Â Frontiers in Bioengineering and Biotechnology. (submitted)
Bonfield, T.L.; Sutton, M.T.; Fletcher, D.R.; Folz, M.A.; Ragavapura, V.; Somoza, R.A.; and Caplan AI. Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium. Stem Cells Transl Med. 2021; 1– 15. PMID: 33943038 https://doi.org/10.1002/sctm.20-0521
Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191
Lennon, D.P.; Somoza, R.A.; Schluchter, M.A.; and Caplan, A.I.: The Habitat Assay, a Platform to Study In Vivo Properties of Human Mesenchymal Stem Cells. Tissue Eng Part A. 2020 26(23-24):1378-1387. PMID: 33107389 PMCID: PMC7759284 (available on 2021-12-01) DOI: 10.1089/ten.TEA.2020.0178
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002/term.2961. [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue Engineering 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002/jor.23820 Abstract
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Human mesenchymal stem cells (MSCs) do not make articular cartilage in vitro: Transcriptome-wide analyses of human neonatal cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering 2017 (Submitted)
Correa D.; Somoza, R.; Lin, P.; Schiemann, W.P.; and Caplan, A.I.: Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. International Journal of Cancer 2016 138(2):417-27

Jean F. Welter

Yi Zhong, Bo Zhang, Rodrigo Somoza, Arnold I. Caplan,Jean F. Welter, and Harihara Baskaran: Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis TISSUE ENGINEERING: Part A, Volume 31, Numbers 1 and 2, 2025.
Jung, H.; Mclellan, P.; Welter, J.F.; and Akkus, O.: Chondrogenesis Mesenchymal Stem Cells via Local Release of TGFβ3 from Heparinized Collagen Biofabric. Tissue Eng Part A. 2021 Nov;27(21-22):1434-1445. DOI: 10.1089/ten.TEA.2020.0383. PMID: 33827271
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 27(19-20):1321-1332. doi: 10.1089/ten.TEA.2020.0144. PMID: 33499734
Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191
Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Larson, B.L.; Yu, S.N.; Park, H.; Estes, B.T.; Moutos, F.T.; Bloomquist, C.J.; Wu, P.B.; Welter, J.F.; Langer, R.; Guilak, F.; and Freed, L.E.: Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds. Journal of Tissue Engineering and Regenerative Medicine. 2019 doi: 10.1002/anie.2019107722019
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 24(8):443-456, 2018, PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, DOI: 10.1007/s10439-018-2067-x
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089/ten.TEA.2017.0438 (Epub ahead of print)</p
Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)
Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)
Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 doi: 10.1016/j.actbio.2017.07.016. [Epub ahead of print]
Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913.
Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering 2016 44(3):733-49.

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