Projects

Interested in working with the Center for Modular Manufacturing of Structural Tissues (CM2oST)? Take a look at our Service Projects (SPs) and Collaborative Projects (CPs), or contact us to start a new project. 

Proposed Service Projects

Locations of Service Project institutions. Red pins: new or continuing projects. Numbers correspond to table on left. Yellow pins: CCMEEC completed projects
Start a New Service Project
  • PI & Institution: Robby Bowles, The University of Utah, Salt Lake City, UT
  • Title: Identification of new target that will drive osteogenesis
  • Funding Source: U. of Utah Start-up Funds and NIH
  • PI & Institution:Tomas Kean, Biionix Cluster, College of Medicine, U. of Central Florida, Orlando, FL
  • Title: Use and validation of chondrocyte cell reporters for cartilage tissue engineering leading to improved in vitro culture and drug discovery
  • Funding Source: Biionix startup funds
  • PI & Institution: Anand R. Kumar, University Hospitals Cleveland, OH
  • Title: Muscle Derived Stem Cells for Healing Volumetric Muscle Loss
  • Funding Source: PSF/MTF Biologics Allograft Tissue Research
  • PI & Institution: Aijun Wang, UC Davis School of Medicine, Davis, CA
  • Title: Manufacturing GMP grade placental MSCs for clinical applications
  • Funding Source: NIH
  • PI & Institution: Alexander Revzin, Mayo Clinic, Rochester, MN
  • Title:Bioreactor process standardization during pancreatic islet differentiation culture
  • Funding Source: NIH
  • PI & Institution: Jeffrey Millman, Ph.D., Washington University School of Medicine, St. Louis, MO
  • Title: Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
  • Funding Source: NIH R01DK127497
  • PI & Institution: Emilio Barbera-Guillem, MD, Ph.D., Celartia® Ltd, Columbus, OH
  • Title: Oxygen monitoring in CAR-T cell therapy production system.
  • Funding Source: Celartia® corporate funds. NIH: 75N91021C00016-0-9999-1
  • PI & Institution:Fernando Albornoz, Inbiocriotec S.A. Valparaiso, Chile
  • Title: Preservation and transport of engineered tissues
  • Funding Source: Inbiocriotec corporate funds
  • PI & Institution: Lisa Larkin, Ph.D., University of Michigan, Ann Arbor, MI
  • Title:Engineering Skeletal Muscle Tissue in STEL Bioreactor on Tissue Foundry Line
  • Funding Source:DOD W911NF-17-3-003
  • PI & Institution: Agustin Martinez, Ph.D.,  Interdisciplinary Center of Neurosciences, Faculty of Science, Valparaiso University, Valparaiso, Chile
  • Co-PI: Caroline Weinstein, Ph.D., Faculty of Pharmacy, Valparaiso University.
  • Title: Development and optimization of a scaffold for the treatment of Venous ulcers
  • Funding Source: ID21I10153, Fondef, Chile
  • PI & Institution: Maneesh Dave, UC Davis
  • Title:Davis, Davis, CA Homing of mesenchymal cells to experimental mouse model of bowel diseases
  • Funding Source: NIH
  • PI & Institution: Aldo R. Boccaccini, Ph.D., University of Erlangen-Nuremberg, Institute of Biomaterials, Erlangen, Germany.
  • Title: Use and validation of sensor/reporters for bone tissue engineering using novel biomaterials and scaffold manufacturing processes.
  • Funding Source:Institute of Biomaterials internal funds

Proposed Collaborative Projects

Locations of Collaborative Project institutions. Blue pins: new or continuing projects. Numbers correspond to table below. Green pins: CCMEEC completed projects
Start a New Collaborative Project
  • Investigator & Institution: Kevin Healy, Ph.D., University of California – Berkeley, Berkeley, CA
  • Title: Non-destructive assessment of cryopreserved microtissues post-thaw.
  • Funding Source: NSF
  • Investigator & Institution: John Moore, B.A., Scientific Bioprocessing, Inc., Pittsburgh, PA
  • Title: Real-time nutrient and metabolite monitoring during cell and tissue culture for quality engineering of tissue-engineered medical products
  • Funding Source: Scientific Bioprocessing, Inc. corporate funds
  • Investigator & Institution: Alexander Revzin, Ph.D., Mayo Clinic, Rochester, MN
  • Title: Bioreactor culture of hPSC spheroids for pancreatic β cells
  • Funding Source:Kieckhefer Foundation
  • Investigator & Institution: George Christ, Ph.D., University of Virginia, Charlottesville, VA
  • Title: Evaluation of novel, non-invasive CQAs for biomanufacturing of TEMPs in a modular, closed-loop bioreactor system
  • Funding Source: NIH, DOD
  • Investigator & Institution: Peter Alexander, Ph.D., Hang Lin, Ph.D., University of Pittsburgh, Pittsburgh, PA
  • Title: Bioreactor control of tissue-chip models for synovial joint pathologies
  • Funding Source: NIH
  • Investigator & Institution:Aaron Haubner, Celartia, Inc., Columbus, OH
  • Title: Developing novel strategies for shipping and storing Tissue-Engineered constructs at room temperature
  • Funding Source: Corporate funds
  • Investigator & Institution: Elizabeth Lipke, Ph.D., Auburn University, Auburn AL
  • Title:RECODE: Directing and Controlling Cardiac Differentiation Through Cellular and Microenvironmental Manipulation and Application of Machine-Learning
  • Funding Source: NSF
  • Investigator & Institution:Julia Oxford, Boise State University, Boise, ID
  • Title: Optimization of the MSC-responsive chondrogenic phenotype towards articular chondrocytes
  • Funding Source: NIH
  • Investigator & Institution: Dimitrios Kouroupis, Ph.D., University of Miami, FL
  • Title: Mesenchymal Stem Cell Functionalization in 3D Manufacturing Settings for Clinical Applications
  • Funding Source: Department start-up funds
  • Investigator & Institution: Sam Senyo, Ph.D., Case Western Reserve University, Cleveland, OH
  • Title: Cardiomyocyte differentiation by combinatorial paracrine signaling
  • Funding Source: Startup and NIH
  • Investigator & Institution: Riccardo Gottardi, Ph.D., Children Hospitals of Philadelphia, PA
  • Title: Bioinstructive reactors for mechanical conditioning of tissues
  • Funding Source: Startup funds
  • Investigator & Institution:Tomás Egaña, SYMBIO2 Inc. and Pontificia Universidad Católica de Chile, Santiago, Chile
  • Title: Transplant organ preservation
  • Funding Source:SYMBIO2 Inc. Corporate funds
  • Investigator & Institution: Eben Alsberg, Ph.D., University of Illinois, Chicago, IL
  • Title: Opposing RNAi molecule gradient constructs to repair osteochondral defects
  • Funding Source: Startup funds
  • Investigator & Institution: Aldo Leal-Egana, Ph.D., University of Heidelberg, Germany
  • Title: Bone osteotropism: Influence of confinement and mechanical properties of the seeds in the selection of the soil
  • Funding Source: LE-3418/4-1
  • Investigator & Institution: Aldo Boccacini, Ph.D., University of Erlangen-Nuremberg, Institute of Biomaterials, Erlangen, Germany
  • Title:Bioactive Glass-derived scaffolds for bone tissue engineering.
  • Funding Source:Institute of Biomaterials internal funds
  • Investigator & Institution:Carolyn Schutt Ibsen, Ph.D., Oregon Health & Science University, Portland, Oregon
  • Title: Energy-responsive biomaterial platforms for regenerative medicine
  • Funding Source: Department Start-Up funds
  • Investigator & Institution: Yolanda Fortenberry, Case Western Reserve University, Cleveland, OH
  • Title: Developing tissue-specific aptamers
  • Funding Source:Department of Biology startup funds
  • Investigator & Institution: Rhima Coleman, Ph.D., University of Michigan, Ann Arbor, MI
  • Title: Identification of –omics signatures related to the chondrogenic potential of hMSC
  • Funding Source: NIH/NSF
Interested in initiating a new service or collaborative project?
Contact us