Projects
Interested in working with the Center for Modular Manufacturing of Structural Tissues (CM2oST)? Take a look at our Service Projects (SPs) and Collaborative Projects (CPs), or contact us to start a new project.
Proposed Service Projects

- PI & Institution: Robby Bowles, The University of Utah, Salt Lake City, UT
- Title: Identification of new target that will drive osteogenesis
- Funding Source: U. of Utah Start-up Funds and NIH
- PI & Institution:Tomas Kean, Biionix Cluster, College of Medicine, U. of Central Florida, Orlando, FL
- Title: Use and validation of chondrocyte cell reporters for cartilage tissue engineering leading to improved in vitro culture and drug discovery
- Funding Source: Biionix startup funds
- PI & Institution: Anand R. Kumar, University Hospitals Cleveland, OH
- Title: Muscle Derived Stem Cells for Healing Volumetric Muscle Loss
- Funding Source: PSF/MTF Biologics Allograft Tissue Research
- PI & Institution: Aijun Wang, UC Davis School of Medicine, Davis, CA
- Title: Manufacturing GMP grade placental MSCs for clinical applications
- Funding Source: NIH
- PI & Institution: Alexander Revzin, Mayo Clinic, Rochester, MN
- Title:Bioreactor process standardization during pancreatic islet differentiation culture
- Funding Source: NIH
- PI & Institution: Jeffrey Millman, Ph.D., Washington University School of Medicine, St. Louis, MO
- Title: Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetes
- Funding Source: NIH R01DK127497
- PI & Institution: Emilio Barbera-Guillem, MD, Ph.D., Celartia® Ltd, Columbus, OH
- Title: Oxygen monitoring in CAR-T cell therapy production system.
- Funding Source: Celartia® corporate funds. NIH: 75N91021C00016-0-9999-1
- PI & Institution:Fernando Albornoz, Inbiocriotec S.A. Valparaiso, Chile
- Title: Preservation and transport of engineered tissues
- Funding Source: Inbiocriotec corporate funds
- PI & Institution: Lisa Larkin, Ph.D., University of Michigan, Ann Arbor, MI
- Title:Engineering Skeletal Muscle Tissue in STEL Bioreactor on Tissue Foundry Line
- Funding Source:DOD W911NF-17-3-003
- PI & Institution: Agustin Martinez, Ph.D., Interdisciplinary Center of Neurosciences, Faculty of Science, Valparaiso University, Valparaiso, Chile
- Co-PI: Caroline Weinstein, Ph.D., Faculty of Pharmacy, Valparaiso University.
- Title: Development and optimization of a scaffold for the treatment of Venous ulcers
- Funding Source: ID21I10153, Fondef, Chile
- PI & Institution: Maneesh Dave, UC Davis
- Title:Davis, Davis, CA Homing of mesenchymal cells to experimental mouse model of bowel diseases
- Funding Source: NIH
- PI & Institution: Aldo R. Boccaccini, Ph.D., University of Erlangen-Nuremberg, Institute of Biomaterials, Erlangen, Germany.
- Title: Use and validation of sensor/reporters for bone tissue engineering using novel biomaterials and scaffold manufacturing processes.
- Funding Source:Institute of Biomaterials internal funds
Proposed Collaborative Projects

- Investigator & Institution: Kevin Healy, Ph.D., University of California – Berkeley, Berkeley, CA
- Title: Non-destructive assessment of cryopreserved microtissues post-thaw.
- Funding Source: NSF
- Investigator & Institution: John Moore, B.A., Scientific Bioprocessing, Inc., Pittsburgh, PA
- Title: Real-time nutrient and metabolite monitoring during cell and tissue culture for quality engineering of tissue-engineered medical products
- Funding Source: Scientific Bioprocessing, Inc. corporate funds
- Investigator & Institution: Alexander Revzin, Ph.D., Mayo Clinic, Rochester, MN
- Title: Bioreactor culture of hPSC spheroids for pancreatic β cells
- Funding Source:Kieckhefer Foundation
- Investigator & Institution: George Christ, Ph.D., University of Virginia, Charlottesville, VA
- Title: Evaluation of novel, non-invasive CQAs for biomanufacturing of TEMPs in a modular, closed-loop bioreactor system
- Funding Source: NIH, DOD
- Investigator & Institution: Peter Alexander, Ph.D., Hang Lin, Ph.D., University of Pittsburgh, Pittsburgh, PA
- Title: Bioreactor control of tissue-chip models for synovial joint pathologies
- Funding Source: NIH
- Investigator & Institution:Aaron Haubner, Celartia, Inc., Columbus, OH
- Title: Developing novel strategies for shipping and storing Tissue-Engineered constructs at room temperature
- Funding Source: Corporate funds
- Investigator & Institution: Elizabeth Lipke, Ph.D., Auburn University, Auburn AL
- Title:RECODE: Directing and Controlling Cardiac Differentiation Through Cellular and Microenvironmental Manipulation and Application of Machine-Learning
- Funding Source: NSF
- Investigator & Institution:Julia Oxford, Boise State University, Boise, ID
- Title: Optimization of the MSC-responsive chondrogenic phenotype towards articular chondrocytes
- Funding Source: NIH
- Investigator & Institution: Dimitrios Kouroupis, Ph.D., University of Miami, FL
- Title: Mesenchymal Stem Cell Functionalization in 3D Manufacturing Settings for Clinical Applications
- Funding Source: Department start-up funds
- Investigator & Institution: Sam Senyo, Ph.D., Case Western Reserve University, Cleveland, OH
- Title: Cardiomyocyte differentiation by combinatorial paracrine signaling
- Funding Source: Startup and NIH
- Investigator & Institution: Riccardo Gottardi, Ph.D., Children Hospitals of Philadelphia, PA
- Title: Bioinstructive reactors for mechanical conditioning of tissues
- Funding Source: Startup funds
- Investigator & Institution:Tomás Egaña, SYMBIO2 Inc. and Pontificia Universidad Católica de Chile, Santiago, Chile
- Title: Transplant organ preservation
- Funding Source:SYMBIO2 Inc. Corporate funds
- Investigator & Institution: Eben Alsberg, Ph.D., University of Illinois, Chicago, IL
- Title: Opposing RNAi molecule gradient constructs to repair osteochondral defects
- Funding Source: Startup funds
- Investigator & Institution: Aldo Leal-Egana, Ph.D., University of Heidelberg, Germany
- Title: Bone osteotropism: Influence of confinement and mechanical properties of the seeds in the selection of the soil
- Funding Source: LE-3418/4-1
- Investigator & Institution: Aldo Boccacini, Ph.D., University of Erlangen-Nuremberg, Institute of Biomaterials, Erlangen, Germany
- Title:Bioactive Glass-derived scaffolds for bone tissue engineering.
- Funding Source:Institute of Biomaterials internal funds
- Investigator & Institution:Carolyn Schutt Ibsen, Ph.D., Oregon Health & Science University, Portland, Oregon
- Title: Energy-responsive biomaterial platforms for regenerative medicine
- Funding Source: Department Start-Up funds
- Investigator & Institution: Yolanda Fortenberry, Case Western Reserve University, Cleveland, OH
- Title: Developing tissue-specific aptamers
- Funding Source:Department of Biology startup funds
- Investigator & Institution: Rhima Coleman, Ph.D., University of Michigan, Ann Arbor, MI
- Title: Identification of –omics signatures related to the chondrogenic potential of hMSC
- Funding Source: NIH/NSF
Interested in initiating a new service or collaborative project?